The most important ingredients

Peptides

Short chains of amino acids - signalling molecules for the skin.

Function: Can support resilience and skin structure, ease wrinkles and firm the skin.

Growth factors

Signalling proteins that can support skin regeneration.

Function: Can support skin renewal, ease wrinkles and improve skin density - a gentle retinol alternative.

ZO-RRS2

Exclusive ZO Skin Health complex from edelweiss and horehound stem cell cultures - a powerful plant-based antioxidant system.

Function: Can neutralise free radicals, ease redness and protect against premature skin ageing caused by environmental stressors.

Application

After cleansing 1-2 pumps apply to clean, dry skin of face and neck. Pat in gently and allow to absorb completely before applying the next product.

Morning and evening use. For best active ingredient absorption, complete the Getting Skin Ready routine first - cleanse, exfoliate, tone.

Tip: Pairs well with Radical Night Repair or Wrinkle + Texture Repair.

Frequently asked questions

What do growth factors do in skincare?

Growth factors are signalling molecules that instruct cells to produce collagen and elastin. As we age, the skin's own growth factor activity decreases — production slows, structure weakens. Plant-based growth factors in this serum mimic these signals and stimulate the skin's repair processes. The result is firmer skin with improved elasticity over time.

Why should Growth Factor Serum be applied in the evening, not the morning?

Growth factors work more effectively during the skin's nocturnal regeneration phase. At night, cell division and repair are at their peak — growth factor signals find more receptive cells. Morning application is not harmful, but the evening application yields stronger results.

Can I combine Growth Factor Serum with my retinol?

Yes, both even support each other. Growth factors instruct cells to produce collagen; retinol stimulates cell renewal, making those cells more active. Using them together is a complementary strategy. Important: Growth Factor Serum before retinol, both in the evening. Start retinol slowly if you are new to it.

What is the dermo-epidermal junction and why is strengthening it important?

The DEJ is the interface between the epidermis (outermost skin layer) and the dermis (connective tissue layer). It is the structural anchor of the skin. When the DEJ weakens, the epidermis and dermis detach — the skin loses firmness, looks thinner, and becomes more prone to wrinkling. Strengthening the DEJ means strengthening this anchor point, which improves the overall architecture of the skin.

How long will it take before I see a difference?

Improved hydration and a more even complexion are noticeable after 3–4 weeks. Deeper effects — firmer skin, reduced fine lines, improved elasticity — typically develop over 8–12 weeks with consistent daily use.

About the brand

ZO Skin Health was developed by Dr. Zein Obagi - one of the world's most renowned dermatologists, with over 35 years of research in Beverly Hills. His principle: the skin is not “repaired” from the outside; instead, the cells themselves are activated. Because collagen, elastin and cell renewal decline with age, ZO products work in a targeted way across different skin layers - as system skincare following established treatment protocols, not as a single product.

Transparency & Mandatory Information

Ingredients (INCI)

Aqua, Cyclopentasiloxane, Dipropylene Glycol, Propylene Glycol, Dimethicone, Glycerin, Dimethicone Crosspolymer, Dimethicone/PEG-10/15 Crosspolymer, PEG-12 Dimethicone Crosspolymer, Butylene Glycol, Dimethicone/Vinyl Dimethicone Crosspolymer, Sodium Phosphate, Panthenyl Triacetate, Phospholipids, Magnesium Sulfate, Hydrolyzed Sericin, Ethyl Linoleate, Buddleja Davidii Meristem Cell Culture, Angelica Polymorpha Sinensis Root Extract, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Lactobacillus/Panax Ginseng Root Extract Ferment Filtrate, Disodium Acetyl Glucosamine Phosphate, Acetyl Tyrosine, Dimethiconol, Oleyl Alcohol, Proline, Parfum, Tocopherol, Beta-Glucan, Adenosine Triphosphate, Hydrolyzed Vegetable Protein, Sodium Chloride, Xanthan Gum, Phenoxyethanol.

Instructions for use

For external use only. Avoid contact with eyes. Reduce or discontinue use if irritation occurs. Keep out of reach of children.

Product Safety & Contact

NOVVIA GmbH ,

Am Lohmühlbach 17
85356 Freising
Deutschland
,

info@NOVVIA.de , +49 8161 96994-0