About iS Clinical
iS Clinical is one of the world's most frequently dermatologist-recommended active brands. Every product is developed in its own laboratory in the USA and contains pharmaceutical actives in particularly high concentrations, so that just a few drops per application are enough. The serums and creams cover a broad spectrum - from anti-ageing and pigment spots to sensitive skin and a weakened skin barrier. At its heart is the patented Extremozyme technology - enzymes from organisms that survive under extreme conditions and that have been shown to protect cell DNA against UV damage. Further key actives: arbutin (plant-based brightener), Centella Asiatica (regenerating) and the Youth Complex (a skin-identical growth-factor technology). We are an authorised iS Clinical retailer in Germany and advise you on choosing the right products.
Dr. med. Niels Freitag added iS Clinical to the range as one of the first brands. In the skincare studio in Cologne we have worked with these products daily for years - the Active Serum in particular has established itself as our best-selling single product across all brands.
Is iS Clinical suitable for your skin?
iS Clinical offers a specialized product for every skin concern - from serums with plant-based acids to sunscreens with DNA repair enzymes. Our AI skin analysis matches your skin profile with the entire range and tells you whether iS Clinical is right for you or what else might be better suited. Free of charge, no appointment needed.
Or get personal advice from our team - via video, phone, or chat. Together, we'll put together your routine.
Frequently asked questions about iS Clinical
What sets iS Clinical apart?
iS Clinical is among the world's most frequently dermatologist-recommended active brands. The products are developed in the brand's own laboratory in the USA and contain pharmaceutical actives in particularly high concentrations. The Active Serum has been our best-selling single product across all five brands for years.
What sets iS Clinical apart from drugstore cosmetics: fewer products, higher active density, results after a few weeks instead of months. Dr. med. Niels Freitag added iS Clinical as one of the first brands to the range and uses it daily in the skincare studio in Cologne.
What's a good way to get started with iS Clinical?
You don't need the whole range - four products are enough for a complete routine. iS Clinical works with a simple 4-step system: cleansing, correction, moisture, protection. A proven starter routine: Cleansing Complex for cleansing, Active Serum as the all-rounder against blemishes, fine lines and an uneven skin tone, Hydra-Cool Serum for moisture, and Extreme Protect SPF 40 as daytime protection. If you're unsure, start our free AI skin analysis - it recommends suitable products based on your skin.
How is the 4-step system from iS Clinical structured?
iS Clinical works with four categories: cleansing, correction, moisture, protection. You choose one product from each category and you have a complete routine. In practice that means, for example: Cleansing Complex (cleansing), Active Serum (correction), Hydra-Cool Serum (moisture), Extreme Protect SPF 40 (protection). The system is deliberately modular - you can swap individual products depending on your skin's needs without rebuilding the whole routine. For sensitive skin you take the Sheald Recovery Balm instead of the Active Serum, the rest stays the same. Four products, one routine, everything covered.
What distinguishes the different iS Clinical serums?
iS Clinical offers several serums with different focuses. The Active Serum is the all-rounder - for blemishes, pigment spots and first wrinkles at the same time. The GeneXC Serum offers intensive vitamin C protection with 20% L-ascorbic acid and extremozymes, the Brightening Serum concentrates on a more even skin tone. For mature skin with loss of elasticity, the Youth Serum is the first choice; the Poly-Vitamin Serum supplies stressed skin with a broad vitamin spectrum. The Hydra-Cool Serum is the moisture specialist and can be combined with any other serum. Super Serum Advance+ combines several of these benefits in one formulation. If you're unsure, start our free skin analysis.
Is iS Clinical suitable for sensitive skin too?
Yes, several products are developed specifically for sensitive and reactive skin. The Hydra-Cool Serum soothes and provides moisture without irritating; the Sheald Recovery Balm strengthens the skin barrier with ceramides. As sun protection, the Extreme Protect SPF 40 is suitable - it contains mineral filters (zinc oxide and titanium dioxide) that sit on the skin instead of penetrating, so it's particularly well tolerated. Just take care with the Active Serum: the pH value of 3.5 can tingle at first. In that case start with one drop every other evening and increase slowly. When in doubt, our team will advise which products suit your skin.