About iS Clinical
iS Clinical is an active skincare brand from the USA. Its formulas combine plant extracts such as willow bark, sugar cane and bilberry with vitamin C, hyaluronic acid and peptides. We stock 28 products from the brand.
The range follows four steps: cleanse, correct, hydrate, protect. Pick one product from each step and your routine is complete.
Cleanse: The Cleansing Complex is a gel with willow bark and sugar cane extract for every skin type. For dry skin there are the Cream Cleanser and the Warming Honey Cleanser.
Correct: The Active Serum contains willow bark extract, sugar cane extract and arbutin. It is designed for skin with blemishes, pigmentation spots and fine lines. For very sensitive skin, the Hydra-Cool Serum is the gentler place to start.
The Retinol+ Emulsion 0.3 contains 0.3 percent retinol with bakuchiol and hyaluronic acid, intended as an entry into retinol care. During the day, add a sunscreen with at least SPF 30. For anti-ageing routines, serums such as the GeneXC Serum with 20 percent L-ascorbic acid, the Youth Serum with peptides and the Super Serum Advance+, which combines vitamin C, arbutin and peptides in one formula, complete the step.
Hydrate: The Hydra-Cool Serum with hyaluronic acid, pantothenic acid and Centella Asiatica can be combined with every other step. The Reparative Moisture Emulsion contains peptides and hyaluronic acid; one to two pumps are enough per application. For very dry skin there is the Sheald Recovery Balm with ceramides.
Protect: The Extreme Protect SPF 40 is a mineral, lightly tinted sunscreen with zinc oxide and titanium dioxide.
For the eye area there are the Youth Eye Complex with peptides and hyaluronic acid and the Eye Complex, and for neck and décolleté the Neckperfect Complex.
In addition there is the Active Peel System, a two-step peel for use at home: 15 applications with pre-portioned pads. Step one contains fruit acids and salicylic acid, step two neutralises. Use it every other day, preferably in the evening. A cool tingling after applying is normal; pause it during acute flare-ups of redness.
If you would rather not put the four steps together yourself, choose one of our three sets with four products each: Couperose-Set, Anti-Aging-Set or Anti-Pigment-Set. The Couperose-Set, for example, combines Cleansing Complex, Hydra-Cool Serum, Reparative Moisture Emulsion and Extreme Protect SPF 40 for skin with couperose.
Where to buy iS Clinical: right here in our shop. We are an authorised iS Clinical retailer in Germany and ship with DHL from Germany, with free shipping within Germany from 100 euros and Samples from 150 euros. The AI skin analysis further down shows you which products suit your skin. Our team from the skincare studio in Cologne is also happy to advise you in person.

Created with AI
Is iS Clinical suitable for your skin?
iS Clinical offers a specialized product for every skin concern - from serums with plant-based acids to sunscreens with DNA repair enzymes. Our AI skin analysis matches your skin profile with the entire range and tells you whether iS Clinical is right for you or what else might be better suited. Free of charge, no appointment needed.
Or get personal advice from our team - via video, phone, or chat. Together, we'll put together your routine.
Frequently asked questions about iS Clinical
What sets iS Clinical apart?
iS Clinical is an active skincare brand from the USA. Its products combine plant extracts such as willow bark, sugar cane and bilberry with vitamin C, hyaluronic acid and peptides. The range follows four steps: cleanse, correct, hydrate, protect.
The most searched products are the Active Serum and the Cleansing Complex. We are an authorised iS Clinical retailer in Germany, and our team in the skincare studio in Cologne works with the products.
What's a good way to get started with iS Clinical?
You don't need the whole range - four products are enough for a complete routine. iS Clinical works with a simple 4-step system: cleansing, correction, moisture, protection. A proven starter routine: Cleansing Complex for cleansing, Active Serum as the all-rounder against blemishes, fine lines and an uneven skin tone, Hydra-Cool Serum for moisture, and Extreme Protect SPF 40 as daytime protection. If you're unsure, start our free AI skin analysis - it recommends suitable products based on your skin.
How is the 4-step system from iS Clinical structured?
iS Clinical works with four categories: cleansing, correction, moisture, protection. You choose one product from each category and have a complete routine. One example: Cleansing Complex (cleansing), Active Serum (correction), Hydra-Cool Serum (moisture), Extreme Protect SPF 40 (protection). The system is deliberately modular: you can swap individual products according to your skin's needs without changing the whole routine. For sensitive skin, use the Sheald Recovery Balm instead of the Active Serum and keep the rest the same.
What distinguishes the different iS Clinical serums?
We stock seven iS Clinical serums. The Active Serum with willow bark extract, sugar cane extract and arbutin is designed for skin with blemishes, pigmentation spots and first lines. The GeneXC Serum contains 20 % L-ascorbic acid (vitamin C) and green tea; during the day, add a sunscreen with at least SPF 30. The Brightening Serum relies on alpha-arbutin for a more even skin tone. The Youth Serum contains peptides and caffeine, while the Super Serum Advance+ combines vitamin C, arbutin and peptides in one formula. The Poly-Vitamin Serum with niacinamide, pantothenic acid and vitamin E is intended for stressed skin. The Hydra-Cool Serum is the moisture specialist and can be combined with any other serum. If you are unsure, start our free skin analysis.
Is iS Clinical suitable for sensitive skin too?
Yes, several products are designed for sensitive skin. With the Hydra-Cool Serum (hyaluronic acid, pantothenic acid, Centella Asiatica) you give your skin moisture, and with the Sheald Recovery Balm you support the skin barrier with ceramides. As a sunscreen, the Extreme Protect SPF 40 contains mineral filters (zinc oxide and titanium dioxide). With the Active Serum, the pH of 3.8 may tingle at first; apply 3 to 5 drops in the evening after cleansing. For very sensitive skin, the Hydra-Cool Serum is the better place to start. If in doubt, our team will advise you on which products suit your skin.
Where can I buy iS Clinical?
Right here in our shop. We are an authorised iS Clinical retailer in Germany. You will find 28 products from the brand, including three sets: the Couperose-Set, the Anti-Aging-Set and the Anti-Pigment-Set.
We ship with DHL from Germany, with free shipping within Germany from 100 euros. Our team answers questions about choosing the right products by phone, email or chat.
What is the iS Clinical Active Serum for?
The Active Serum is designed for skin with blemishes, pigmentation spots, fine lines and enlarged pores. It contains willow bark extract, sugar cane extract, bilberry extract and arbutin in a formula with a pH of 3.8. A slight tingling when applying it is normal.
Apply 3 to 5 drops in the evening after cleansing. Use retinol on a different evening. If you use prescription products on your skin, consult your doctor before use. For very sensitive skin, the Hydra-Cool Serum is the gentler place to start.
Is 0.3 percent retinol a lot?
No, 0.3 percent is a low concentration for getting started. The Retinol+ Emulsion 0.3 from iS Clinical contains this amount, together with bakuchiol, hyaluronic acid and squalane in a light emulsion. Higher concentrations of 0.5 to 1 percent lead to redness and flaking more often.
Start with 2 to 3 evenings a week and increase if your skin tolerates it well. Retinol increases the skin's sensitivity to light: use a sunscreen with at least SPF 30 every day. Manufacturer's note: use during pregnancy, breastfeeding or on children under 12 years is not recommended.

























